Mark Wigglesworth is recognised internationally for his masterly interpretations both in the opera house and in the concert hall, highly detailed performances that combine a finely considered architectural structure with great sophistication and rare beauty. As a highly respected conductor, he has forged many enduring relationships with orchestras and opera companies across the world, conducting repertoire ranging from Mozart to Boulez.

Highlights have included performances with the Berlin Philharmonic, Royal Concertgebouw, London Symphony, Boston Symphony, New York Philharmonic, Philadelphia Orchestra, Chicago Symphony, Los Angeles Philharmonic, Cleveland Orchestra, and Tokyo Symphony. Recordings include a critically acclaimed cycle of the Shostakovich Symphonies with the BBC National Orchestra of Wales and the Netherlands Radio Philharmonic, Mahler's Sixth and Tenth Symphonies with the Melbourne Symphony, a disc of English music with the Sydney Symphony, Britten's Peter Grimes with Glyndebourne, and the Brahms Piano Concertos with Stephen Hough.

In opera, Wigglesworth has enjoyed long relationships with The Royal Opera House, Covent Garden (Die Meistersinger von Nürnberg, Rise and Fall of Mahagonny, From the House of the Dead, La Clemenza di Tito, Hansel and Gretel) and English National Opera (Lady Macbeth of Mtsensk, Cosi fan Tutti, Falstaff, Katya Kabanova, Parsifal, Force of Destiny, Magic Flute, Jenufa, Don Giovanni, Lulu), and operatic engagements elsewhere include The Metropolitan Opera, New York (The Marriage of Figaro, Orfeo), as well as at The Bavarian State Opera, Opéra National de Paris, and the Teatro Real, Madrid. In 2017, he received the Olivier Award for Outstanding Achievement in Opera.

He has written articles for The Guardian and The Independent, and made a six-part TV series for the BBC entitled Everything to Play For. His book The Silent Musician: Why Conducting Matters is published by Faber & Faber, and has been translated into Spanish and Chinese. He has held positions as Associate Conductor of the BBC Symphony, Principal Guest Conductor of the Swedish Radio Symphony and the Adelaide Symphony, Music Director of the BBC National Orchestra of Wales and English National Opera, and in September 2024, became Chief Conductor of the Bournemouth Symphony Orchestra.